Protein Modification Reagents
Sigma Aldrich Fine Chemicals Biosciences Pepsin from Porcine Gastric Mucosa | 9001-75-6 | MFCD00081840 | 100g
Pepsin from Porcine Gastric Mucosa | 9001-75-6 | MFCD00081840 | 100g
Worthington Biochemical Corporation COLLAGENASE TYPE 4 100MG
Collagenase, Type 4,100 MG, Prepared to contain lower tryptic activity levels to limit damage to membrane proteins and receptors but with normal to above normal collagenase activity,Source: Clostridium histolyticum,Store at 2-8degreeC
Worthington Biochemical Corporation TRPYSIN TPCK TREATED
Chromatographically purified trypsin treated with L-(tosylamido-2-phenyl) ethyl chloromethyl ketone (TPCK) to inhibit contaminating chymotryptic activity according to Kostka, V., and Carpenter, F.H.: JBC, 239, 1799 (1964).
![Medchemexpress LLC 3-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]propanoic acid | 663921-15-1 | MFCD21607085 | 99.9% | 265.30 g/mol | C11H23NO6 | 1 G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000202923.png-250.jpg)
Medchemexpress LLC 3-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]propanoic acid | 663921-15-1 | MFCD21607085 | 99.9% | 265.30 g/mol | C11H23NO6 | 1 G
NH2-PEG4-CH2CH2COOH is an amine-terminated, four-unit polyethylene glycol (PEG) linker with a terminal propanoic acid. It is intended for use in bioconjugation workflows such as antibody-drug conjugate (ADC) and PROTAC linker synthesis and is supplied as an off-white to light yellow solid with high reported purity.
- cleavable four-unit peg linker suitable for ADC and PROTAC synthesis.
- amine-terminated functionality for facile conjugation to drugs or linkers.
- high purity (≈99.9%) for research applications.
- molecular weight around 265.30 g/mol and formula C11H23NO6.
- available in small research pack sizes (e.g., 100 mg-10 g).
- store sealed, away from moisture and light; for solutions store at -80°C (long term) or -20°C (short term).
Medchemexpress LLC E3 LIGASE LIGANDLINKER2(100MG)
Pomalidomide-PEG4-Ph-NH2 (Synonyms: Cereblon Ligand-Linker Conjugates 9; E3 Ligase Ligand-Linker Conjugates 2). Purity: >98.0%.CAS 1818885-63-0
Medchemexpress LLC NHS-PEG2-SS-PEG2-NHS | 96.7% | 580.63 g/mol | C22H32N2O12S2 | 5 MG
NHS-PEG2-SS-PEG2-NHS is a cleavable four-unit polyethylene glycol (PEG) linker with N-hydroxysuccinimide (NHS) ester end groups and a disulfide (SS) cleavable junction, supplied for use in antibody-drug conjugate synthesis and other bioconjugation applications.
- Cleavable disulfide bond enables reductive release of payloads.
- Hydrophilic PEG spacer improves solubility and reduces aggregation.
- NHS ester end groups provide rapid amine coupling to proteins.
- Moderate molecular weight supports spacer function without excessive steric bulk.
- Available in small research sizes suitable for conjugation optimization.
Medchemexpress LLC HY-128716A 100mg Medchemexpress, Pomalidomide-PEG3-C2-NH2 (TFA) CAS: Purity:>98%
Medchemexpress, HY-128716A 100mg Pomalidomide-PEG3-C2-NH2 (TFA) CAS: Pomalidomide-PEG3-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
eMolecules 20-(Amine-PEG3-ethylcarbamoyl)nonadecanoic-t-butyl ester | Broadpharm |572.872 | C32H64N2O6 | 0.000 | CC(C)(C)OC(=O)CCCCCCCCCCCCCCCCCCC(=O)NCCOCCOCCOCCN | 100mg | 784455341
20-(Amine-PEG3-ethylcarbamoyl)nonadecanoic-t-butyl ester | Broadpharm |572.872 | C32H64N2O6 | 0.000 | CC(C)(C)OC(=O)CCCCCCCCCCCCCCCCCCC(=O)NCCOCCOCCOCCN | 100mg | 784455341
Medchemexpress LLC Dspe-peg-alkyne (MW 2000) | 85.0% | 2000 (Average) | 100 MG
DSPE-PEG-alkyne (MW 2000) is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. It can be used in drug delivery research.
- Peg lipid
- Can improve the delivery efficiency of poorly soluble drugs
- Can improve the tissue specificity of poorly soluble drugs
Medchemexpress LLC m-PEG5-azide | 1202681-04-6 | 100 MG
m-PEG5-azide is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Azide group. It can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing Alkyne groups, and also strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. PROTACs themselves contain two distinct ligands connected by a linker; one targets an E3 ubiquitin ligase and the other targets the desired protein, leveraging the intracellular ubiquitin-proteasome system for selective protein degradation.
- PEG-based PROTAC linker
- Click chemistry reagent with azide group
- Facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Enables strain-promoted alkyne-azide cycloaddition (SPAAC)
- Useful in PROTAC synthesis
- Supports selective protein degradation via ubiquitin-proteasome system
Medchemexpress LLC Mal-PEG2-Val-Cit-PAB-OH | 2055041-38-6 | 99.5% | 618.68 g/mol | C29H42N6O9 | 5 MG
Mal-PEG2-Val-Cit-PAB-OH is a cleavable antibody-drug conjugate (ADC) linker featuring a maleimide group, a PEG2 spacer, a valine-citrulline dipeptide cleavable linker, and a para-aminobenzyl (PAB) self-immolative spacer. It is supplied as a solid for research use and is intended for use in ADC and PROTAC synthesis.
- Cleavable Val-Cit dipeptide for enzyme-triggered payload release.
- Maleimide functional group enables thiol conjugation to antibodies or payloads.
- PEG2 spacer improves solubility and flexibility of the linker.
- PAB self-immolative spacer enables payload release after enzymatic cleavage.
- High purity (99.49% by COA) and molecular weight ~618.68 g/mol.
Medchemexpress LLC Propargyl-PEG2-CH2COOH | 944561-46-0 | 95.0% | 202.20 | 100 MG
Propargyl-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Peg-based PROTAC linker
- Click chemistry reagent
- Contains an Alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups
Medchemexpress LLC Boc-NH-PEG4-C2-Boc | 2138484-13-4 | 421.53 | 25 MG
Boc-NH-PEG4-C2-Boc is a PEG-based PROTAC linker used in the synthesis of Proteolysis Targeting Chimeras (PROTACs). These molecules are designed to selectively degrade target proteins by exploiting the intracellular ubiquitin-proteasome system. PROTACs feature two different ligands connected by a linker, where one ligand targets an E3 ubiquitin ligase and the other targets a specific protein.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- PROTACs contain two ligands connected by a linker
- Targets an E3 ubiquitin ligase
- Targets a specific protein
- Exploits the intracellular ubiquitin-proteasome system for selective protein degradation